3 Breakthrough Studies That Prove Fatigue Isn’t Permanent
By John Allen Mollenhauer, “JAM” | Founder, Regenus Center & Creator of the Performance Lifestyle® at Performany.
For decades, scientists have been trying to understand what drives chronic fatigue—and more importantly, how to resolve it. The good news? New research is proving that fatigue isn’t a life sentence. It’s a signal—and when you respond to it through light, movement, and holistic recovery practices, your body can do what it’s designed to do: heal and regenerate.
What you’ll discover is that what often feels “negative” is actually the body’s intelligent, adaptive response—a big-picture corrective action designed to help you heal. Fatigue, inflammation, and even certain symptoms are not failures; they’re signals that your body is working to protect, repair, and restore balance.
This isn’t about simply moving from traditional medicine to alternative medicine. It’s about taking the next leap—into lifestyle medicine and human optimization, aka biohacking—where you begin to understand human performance and the lifestyle it bridges you to, called the Performance Lifestyle®.
Watch this video for more insight into how your body’s natural intelligence is always working for you, not against you. It’s on the thyroid but for the first half it largely speaks to the the body’s intelligent adaptive responses.
Here are three recent studies worth paying attention to.
Discovery #1: Light Is Medicine
Study: Effects of Bright Light Therapy on Fatigue and Cognitive Function in Chronic Fatigue Syndrome: A Randomized Controlled Crossover Study (PMID: 40120538)
In this trial, 36 people with chronic fatigue were given full-spectrum bright light boxes (10,000 lux) to use at home—the same intensity and wavelength range as natural sunlight.
After just two weeks, participants reported:
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Significant improvements in fatigue scores
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Better cognitive function, as measured by the Test of Attentional Performance
Most of us spend 90% of our lives indoors under artificial lighting that never delivers the full range of light our biology expects. Full-spectrum light—and even more so, red and near-infrared wavelengths—activate the mitochondria, the engines of your cells.
This is in part the science behind photobiomodulation, one of Regenus Center’s cornerstone technologies. It’s light as medicine—helping your cells recharge and restore the very energy that drives life.
Discovery #2: Movement Works Magic
Study: Effectiveness of Exercise Interventions for Post-COVID-19 Fatigue: A Single-Blind Randomized Controlled Trial (PMID: 39978856)
In this study, 181 people recovering from post-viral fatigue were assigned to three groups:
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A face-to-face exercise program
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An online exercise program
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Usual care
Both exercise groups improved, with the face-to-face group walking 52 meters farther in standardized walking tests, and the online group 34 meters farther.
Even more encouraging, both groups showed improved immune function, with measurable increases in naïve and memory CD8+ T-cells.
The key takeaway? This wasn’t “pushing through” fatigue—it was therapeutic movement that helped the body re-establish healthy circulation, energy flow, and cellular communication.
At Regenus Center, we teach proactive recovery, enabling you to move better and have more energy to move.
Discovery #3: Online Support Helps the Body Heal
Study: Efficacy of a 12-Week Online Multicomponent Program for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Randomized Controlled Trial (PMID: 38127508)
In this large-scale study, 428 participants with CFS/ME engaged in a 12-week online recovery program combining:
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Pain and fatigue education
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Gentle exercise and brain retraining
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Mindfulness and nervous system regulation
The results were remarkable:
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Significant improvements in fatigue, pain, anxiety, and depression
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Better physical function and quality of life
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A 19% reduction in overall symptom risk compared to usual care
This confirms what we see every day: recovery isn’t just physical—it’s bio-psycho-social. The brain and body must both feel safe, supported, and resourced for true healing to take place.
The Takeaway: Your Body Isn’t Broken—it’s Stuck in Survival Mode
These studies confirm a lot of what the Regenus Center philosophy is built on: your body’s energy system isn’t failing—it’s fatigued from constant overdrive.
Through targeted advanced red light therapy, called photobiomodulation, gentle movement, and structured recovery, you can flip the switch from “survive” to “regenerate.”
At Regenus Center, we combine these evidence-based technologies—Photobiomodulation, PEMF, Whole-Body Vibration, and Advanced Recovery Chambers—with a system of lifestyle principles and protocols designed to restore your natural rhythm and resilience.
With the principles of The 7-Day Energy Rhythm & Reset Blueprint, The BioVitality Protocol, and Revitalize,
you prime yourself to unlock your body’s resilience and start living an energy-first, healthy high-performance lifestyle—
a lifestyle that fully supports you and what you are up to in the world.
You can’t outthink or outwork fatigue.
But you can recover from it—if you know how to regenerate.
Ready to experience it for yourself?
Start with one proactive recovery session this week.
You’ll know, within minutes, that your body is finally doing what it’s needed most all along—
to regenerate.
